Antigens and Antibodies Lesson Plan: Blood Typing Game

Grade Levels: 9-12

In this lesson plan, which is adaptable for grades 9-12, students use BrainPOP resources (including an online game) to differentiate between blood group and blood type. Students will explore how antigens and antibodies affect blood typing, identify the number of blood types that exist and their differences, and investigate the reaction of two incompatible blood cells in a transfusion.

Lesson Plan Common Core State Standards Alignments

Students will:

  1. Differentiate between blood group and blood type.
  2. Explain how antigens and antibodies affect blood type.
  3. Identify the number of blood types that exist and their differences.
  4. Explain the reaction of two incompatible blood cells in a transfusion.



transfusion; hemolysis; blood group; rh factor; red blood cells; ABO blood system; antigens and antibodies; immune system; universal donor


Consider how you will establish students' background knowledge prior to this lesson. A hands-on lab for blood typing is an ideal way to prepare students for more in-depth study. Another option is use the Blood Typing Game as an introduction to the unit, as students will learn many of the basic concepts through game play.

The Blood Typing Game from helps students understand blood typing through visual reinforcement. It graphically illustrates the concept of typing blood and the importance of transfusing other blood types safely in an emergency situation. Through game play, student will learn to understand the different types of blood and how they can and cannot work together. For a more detailed description of how the game works, download the document listed at the bottom of the lesson plan under 'Downloadable Resources'.

Before beginning this lesson, print the Vocabulary page and the Blood Groups FYI and make photocopies for students.

Lesson Procedure:

  1. Ask students: Do you know anyone who donates blood? Why do you think they do so? Why is it important to have blood banks available?
  2. Have students take the blood types Quiz as a quick way to find what students have retained from your previous instruction on blood typing. Address any confusion students still hold on the topic.
  3. Pass out the Vocabulary page to assist students in note-taking. Provide several minutes for students to talk with a partner about the terms and record their current understandings.
  4. Watch the Blood Types Movie as a class. Make sure the closed captioning is on to help students process the information and record definitions on their papers. Provide several minutes afterward for students to make additions and edits to their vocabulary page, and discuss it with a partner.
  5. Explain to students they will be playing an interactive online game to help reinforce their knowledge about blood types. Tell the class, "You will be playing the role of doctors and nurses who need to test a patient to determine his/her blood type. You will get 3 tries for each patient. Though the game will give you hints, think things through carefully and be sure to read any information provided."
  6. Depending on your students' needs, you may want to do a demonstration at this time. You can show students how to move the needle, drop blood into beakers, etc. The section called "How to Play" provides opportunities to practice and can be useful for your demo. To satisfy students' curiosity, you may want to show them what happens when they get all three tries wrong, and then encourage them to get the right answers when they attempt the game themselves.
  7. Read through the Help button information together so that students know how to use that resource if they get stuck. Remind them that they can also use BrainPOP for a review. Pass out the Blood Groups FYI if you want students to have that as a reference during game play.
  8. Allow time (about 15 minutes) for students to play in pairs or individually on computers. Invite students to rate and comment on the game, as long as it's a "quality" comment. Make sure expectations are clear.
  9. When students are done, have them complete a written reflection on their learning. Display the following questions for students to respond to: 1) Were you hired? What was your score (out of 5 blood drops)? 2) What information would someone need to know in order to play this game? 3) Would you recommend this game to other students? Why or why not?
  10. Close the lesson by showing the Cassie & Rita Comic for a laugh.

Extension Activity:

For homework or as a follow up activity, have students read the Around the World FYI . Have them ask a few friends or family members if they know their blood type. Then, compare their personalities to the generalities listed for each blood type in Japanese culture. Do they match up? Do students know what their blood type is? Do students' own personalities match up with the chart?

You may also want to check out the other Science Games and Health Games featured in GameUp.

BrainPOP Movies:

Blood Types
Circulatory System
Blood (Activity Page Answer Key)